Current Issue May 2012, Vol. 8, No. 3

Featured Articles

Alzheimer’s disease: Pathogenesis and prevention
May 2012 (Vol. 8 | No. 3 | Pages 227-233)
Heiko Braak, Kelly Del Tredici
The draft “National Plan” to address Alzheimer's disease - National Alzheimer's Project Act (NAPA)
May 2012 (Vol. 8 | No. 3 | Pages 234-236)
Zaven S. Khachaturian, Ara S. Khachaturian, William Thies
The epidemiology of Alzheimer’s disease: Laying the foundation for drug design, conduct, and analysis of clinical trials
May 2012 (Vol. 8 | No. 3 | Pages 237-242)
Kristine Yaffe, Michael Tocco, Ronald C. Petersen, Catherine Sigler, Leah C. Burns, Christel Cornelius, Ara S. Khachaturian, Michael C. Irizarry, Maria C. Carrillo
An investigation of PreMCI: Subtypes and longitudinal outcomes
May 2012 (Vol. 8 | No. 3 | Pages 172-179)
David A. Loewenstein, Maria T. Greig, John A. Schinka, Warren Barker, Qian Shen, Elizabeth Potter, Ashok Raj, Larry Brooks, Daniel Varon, Michael Schoenberg, Jessica Banko, Huntington Potter, Ranjan Duara
Effects of Food and Drug Administration-approved medications for Alzheimer’s disease on clinical progression
May 2012 (Vol. 8 | No. 3 | Pages 180-187)
Michelle M. Mielke, Jeannie-Marie Leoutsakos, Chris D. Corcoran, Robert C. Green, Maria C. Norton, Kathleen A. Welsh-Bohmer, JoAnn T. Tschanz, Constantine G. Lyketsos

Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging
26 April 2012
Daniel Bos, Meike W. Vernooij, Suzette E. Elias-Smale, Benjamin F.J. Verhaaren, Henri A. Vrooman, Albert Hofman, Wiro J. Niessen, Jacqueline C.M. Witteman, Aad van der Lugt, M. Arfan Ikram
Abstract: Background: Increasing evidence suggests a role of atherosclerosis in the pathogenesis of cognitive impairment and dementia. Calcification volume measured with computed tomography (CT) is a ...
Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus
23 April 2012
Michael L. Johnson, Niraj Parikh, Mark E. Kunik, Paul E. Schulz, Jeetvan G. Patel, Hua Chen, Rajender R. Aparasu, Robert O. Morgan
Abstract: Background: Diabetes and hypertension are independent risk factors for dementia, and hypertension may increase this risk in patients with diabetes. It is unclear whether antihypertensive dru...
Fire in the ashes: Can failed Alzheimer’s disease drugs succeed with second chances?
05 April 2012
Robert E. Becker, Nigel H. Greig
Abstract: Background: Since Cognex, more than 200 Alzheimer’s disease (AD) drug candidates have failed. Investigations have identified vulnerabilities of these AD drug developments to methodological e...
Gaining precision on the Alzheimer’s Disease Assessment Scale-cognitive: A comparison of item response theory-based scores and total scores
05 April 2012
Steve Balsis, Alexis A. Unger, Jared F. Benge, Lisa Geraci, Rachelle S. Doody
Abstract: Background: The Alzheimer’s Disease Assessment Scale-cognitive (ADAS-cog) is a commonly used measure for assessing cognitive dysfunction in patients with Alzheimer’s disease (AD). The measur...
Butyrylcholinesterase genotype and gender influence Alzheimer’s disease phenotype
09 March 2012
Roger M. Lane, Yunsheng He
Abstract: Retrospective data are presented to support a spectrum of early Alzheimer’s disease (AD) along a continuum defined by gender and genotype. The putative neurodegenerative mechanisms driving d...

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2011 Alzheimer’s disease facts and figures
March 2011 (Vol. 7 | No. 2 | Pages 208-244)
Alzheimer’s Association
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
May 2011 (Vol. 7 | No. 3 | Pages 263-269)
Guy M. McKhann, David S. Knopman, Howard Chertkow, Bradley T. Hyman, Clifford R. Jack, Claudia H. Kawas, William E. Klunk, Walter J. Koroshetz, Jennifer J. Manly, Richard Mayeux, Richard C. Mohs, John C. Morris, Martin N. Rossor, Philip Scheltens, Maria C. Carrillo, Bill Thies, Sandra Weintraub, Creighton H. Phelps
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
May 2011 (Vol. 7 | No. 3 | Pages 257-262)
Clifford R. Jack, Marilyn S. Albert, David S. Knopman, Guy M. McKhann, Reisa A. Sperling, Maria C. Carrillo, Bill Thies, Creighton H. Phelps
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
May 2011 (Vol. 7 | No. 3 | Pages 270-279)
Marilyn S. Albert, Steven T. DeKosky, Dennis Dickson, Bruno Dubois, Howard H. Feldman, Nick C. Fox, Anthony Gamst, David M. Holtzman, William J. Jagust, Ronald C. Petersen, Peter J. Snyder, Maria C. Carrillo, Bill Thies, Creighton H. Phelps
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
May 2011 (Vol. 7 | No. 3 | Pages 280-292)
Reisa A. Sperling, Paul S. Aisen, Laurel A. Beckett, David A. Bennett, Suzanne Craft, Anne M. Fagan, Takeshi Iwatsubo, Clifford R. Jack, Jeffrey Kaye, Thomas J. Montine, Denise C. Park, Eric M. Reiman, Christopher C. Rowe, Eric Siemers, Yaakov Stern, Kristine Yaffe, Maria C. Carrillo, Bill Thies, Marcelle Morrison-Bogorad, Molly V. Wagster, Creighton H. Phelps

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Alzheimer's & Dementia: The Journal of the Alzheimer's Association is published by Elsevier for the Alzheimer's Association.

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The Alzheimer's Association is the leading, global voluntary health organization in Alzheimer care and support, and the largest private, nonprofit funder of Alzheimer research.

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